Success Stories: EB‑1A Approved for Computational Biology and Biomedical Data Science Researcher Advancing Infectious‑Disease Diagnostics and Precision Therapies following RFE

Case Summary:      North America Immigration Law Group (NAILG) framed this EB‑1A case around the client’s work, turning complex omics and clinical data into actionable tools for public health. The petition emphasized advances in blood‑based biomarkers to improve tuberculosis detection, systems‑level maps of host‑response networks, and multi‑scale models that guide drug combinations and personalized treatment. Research Focus and Contributions

• Built an unbiased pipeline combining RNA‑seq with network mining to define a concise gene signature for pulmonary TB diagnosis.
• Performed a meta‑analysis of whole‑blood transcriptomes within a protein‑interaction framework to uncover a common, treatment‑responsive core disease network.
• Linked drug transcriptomics, pharmacokinetics, and clinical data in multi‑scale, multimodal models to rank combination regimens and predict outcomes.

Research Impact and Metrics

• 9 journal articles and 1 conference paper.
• 241 total citations across independent teams.
• At least 14 invited manuscript reviews for international journals.

Here is an anonymized excerpt from a recommendation letter that underscores the practical impact of her work: “The [client’s] finding of a 10‑gene blood‑based signature for tuberculosis. Using RNA‑sequencing across nearly 60,000 genes and a molecular interaction network, the [client] selected the most impactful contributors to the TB phenotype; the resulting 10‑gene signature discriminates TB from other diseases with a .74 accuracy rate. By selecting a minimal number of genes, the [client] enabled more accessible diagnostics in clinical settings, and the dynamic changes in these genes during active disease point to potential therapeutic targets.” Demonstrating Extraordinary Ability NAILG met the EB‑1A criteria by documenting: judging the work of others through repeated journal review invitations; original contributions of major significance adopted by researchers working on TB, malaria, COVID‑19, and antiviral therapy design; and authorship in selective venues with objective indicators of influence, including a top‑decile paper in its field. Well Positioned for Continued Innovation The client’s training and ongoing industry leadership role show the capacity to translate algorithms and network models into tools for diagnostics and therapy design, with expert letters and funding history in the record supporting sustained impact. Approval and Outcome Following an RFE that we addressed with targeted evidence, USCIS approved the petition in 11 months and 14 days. NAILG is proud to have guided this EB‑1A case to approval and looks forward to the client’s continuing contributions to data‑driven diagnostics and precision therapies in the United States.