Success Stories: Exploring the Genetic Blueprint of the Human Brain: A Neurobiologist's EB-2 NIW Victory

Case Summary:     

In the complex landscape of neuroscience, few areas of study are as groundbreaking and nationally impactful as understanding the human brain at a genetic level. One postdoctoral research fellow from China has made a significant mark in this domain. With the support of NAILG, this scientist has secured EB-2 NIW (National Interest Waiver) approval for their work in neurobiology, which investigates the genetic origins and evolutionary development of human brain function.

Decoding Human Brain Development through De Novo Genes

At the heart of the client’s research is a pioneering exploration of de novo genes—newly formed genes that did not evolve from pre-existing ones. Using comparative genomics, single-cell multi-omics, and biochemical methods, the client has focused on human-specific genes such as SP0535, a gene shown to be vital for cortical expansion and folding. These findings do not merely add to the scientific literature—they reshape it.

By employing transgenic animal models and stem-cell-derived cortical organoids, the client demonstrated how such genes contribute to neural development and influence brain structure. Their work also revealed key interactions between SP0535 and ATP1A1, implicating them in cell proliferation during brain formation—insights that are central to addressing neurodevelopmental and neurodegenerative disorders.

Research Productivity and Scientific Reach

● 5 peer-reviewed journal articles, including one first-authored and one co-first-authored

● 49 citations, with multiple articles among the top 0.1%, 10%, and 20% most-cited publications in Neuroscience & Behavior for their respective years

● Grants awarded by the National Natural Science Foundation of China, supporting globally relevant biomedical innovation

The client’s findings have been featured in high-impact journals such as Nature Ecology & Evolution, Science Advances, and Advanced Science. These publications have garnered attention from peers worldwide and are already cited in fields ranging from evolutionary biology to neuropharmacology.

Expert Validation from the Global Scientific Community

Perhaps the most convincing support came from respected peers, including an independent recommender who emphasized:

“[Client’s] use of multi-omics approaches to identify human-specific pathways and genes for brain development has further enhanced the targeting and treatment of related conditions such as autism and Alzheimer’s disease. Her research thus dually boosts existing knowledge about human brain development and improves medical outcomes, making it highly beneficial to both global and national public health interests.”

Multiple independent letters of recommendation confirmed the originality, technical rigor, and utility of the client’s contributions, with particular emphasis on how her discoveries are helping reshape prevailing narratives in neurobiology.

Building a Research Pathway Beneficial to the U.S.

The client’s work not only meets, but exceeds, the Dhanasar standard:

● Substantial merit: Her focus on brain genetics directly supports national public health by identifying therapeutic targets for Alzheimer’s, autism, and psychiatric illnesses.

● National importance: With mental illness costing the U.S. an estimated $282 billion annually, her research aligns with urgent health and economic priorities.

● Well-positioned: Backed by elite education, cutting-edge training, and a proven publication record, she is currently engaged in related research at a leading U.S. medical institution.

Fast and Impactful Outcome

Filed on June 24, 2024, and approved by June 26, 2025, her petition was a clear demonstration of her value to the United States. The success underscores the power of precision legal strategy, strong evidence, and authentic scientific contributions.

By illuminating the origin and function of genes that make the human brain uniquely complex, this neurobiologist is helping the U.S. lead in the fight against neurological disease. NAILG is proud to have helped deliver this approval, ensuring her essential work can continue to thrive on American soil.